Pre-clinical Assays
Mitigate risk & reduce time-to-market, ideal for immunotherapies.
In-vitro panel & In/Ex-vivo PK/PD
In-vitro Panel
Prepare PD/PK studies with effective data. From target to therapeutic effect.
Mode of action
Target binding
Affinity of drug-target binding
Cell based assays
Native receptor recognition
Cytokine release
Safety
Cross reactivity testing
Specificity studies
In/ex-vivo PK/PD
Relevant data from less animals and more ex-vivo human testing. From therapeutic effect to clinical file.
Personalized pharmacodynamic
Target binding
Affinity of drug – Cell based assays – Native receptor – Cytokine release
Biomarker expression
Pharmacokinetic
Drug level
Safety
Immunogenicity
ADA
Therapeutic range
Trough – Toxic lvl
Cytokine release
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